Brain Swelling and Brain Bleeding: “Lilly Drug Slows Alzheimer’s by 60% for Mildly Impaired Patients in Trial”
July 17th, 2023Via: Reuters:
Lilly’s study showed that brain swelling, a known side effect of amyloid-clearing antibodies, occurred in more than 40% of patients with a genetic predisposition to develop Alzheimer’s.
The company had previously reported that 24% of the overall donanemab treatment group had brain swelling. Brain bleeding occurred in 31% of the donanemab group and about 14% of the placebo group.
The deaths of three trial patients were linked to the treatment, researchers reported.
In other news:
Nicotinamide Restores Cognition in Alzheimer’s Disease Transgenic Mice
A spoonful of olive oil daily could save your brain from dementia
Nicotinamide/niacinamide’s in my supplement stack, 500mg/day.
Got onto it after evidence it boosted DNA repair in skin, so seemed reasonable to expect it did the same for the rest of the body. It’s also a potent immune-booster for infected wounds/skin/MRSA at higher doses, and it’s a poor man’s replacement for NMN, which boosts NAD+, which protects mitochondrial health…and boosts DNA repair.
Good info, Kevin & Dennis.
This study is the latest in a series by an international group of researchers who are pursuing a drug cure, funded by drug companies. The other side of the coin is that there’s plenty of research on genetic engineering to prevent Alzheimer’s, funded by GE companies. So it’s a drug vs. anatomy and physiology. Maybe someday the two approaches will be combined?
A recent review article on GE:
CRISPR-Cas9 in Alzheimer’s disease: Therapeutic trends, modalities, and challenges.
Chacko L, et al. Drug Discov Today. 2023 Jun 7;28(8):103652.
https://pubmed.ncbi.nlm.nih.gov/37290639/
I’d rather swallow a pill, even with a 24% chance of getting worse, than have my genes scrambled. Just the thought makes my brain swell.
The study discussed in the Reuters article, which gives percentages of adverse effacts, is at:
https://pubmed.ncbi.nlm.nih.gov/37459141/
Now I will read up on nicotinamide.
500mg/day, well done! Do you still get the flush? I’ve been taking it for about a year and I can still get a flush sometimes after a meal with only 100mg.
I once had some 250mg niacin/B3 pills and after taking one I’d have to write off the next 20 minutes, sit down, and brace for lift-off.
I still sometimes get a slight flush even from the 25mg or so I now take (I’m not as brave as you! I break up a 100mg tablet) but niacinamide is the non-flushing form.
I take niacin as nicotinic acid. It’s the maximum flush form. Dr. Wolfson said in a podcast somewhere that it’s the form to take for maximum benefit for heart health. But, wow, the niacin flush from that stuff is powerful.
I went digging…a LOT of stuff coming out about B3’s benefits, but this summed up what I found:
“While most of the biochemical functions of vitamin B3 can be performed either by niacin or niacinamide, only niacin influences serum lipid levels. In addition, niacin has a vasodilatory action, which does not appear to occur with niacinamide.”
From: https://www.naturopathicce.com/natnotes/niacinamide/
So, niacin is best for heart/lipids/vasodilation and niacinamide seems to be best for DNA/mitochondria though there’s a lot of crossover between the two, e.g. both boost autophagy (cellular quality control) and provide physiological benefits similar to fasting.
BTW, this piece of crap article, which disingenuously blames niacin for the drug Merck added to it, popped up in the top results:
https://www.livescience.com/46839-dangers-of-niacin.html
Thanks, Dennis!