Plastic Chemical Phthalate Causes DNA Breakage and Chromosome Defects in Sex Cells
October 25th, 2024Via: MedicalXpress:
A new study conducted on roundworms finds that a common plastic ingredient causes breaks in DNA strands, resulting in egg cells with the wrong number of chromosomes. Monica Colaiácovo of Harvard Medical School led the study, which was published October 24 in the journal PLOS Genetics.
Benzyl butyl phthalate (BBP) is a chemical that makes plastic more flexible and durable, and is found in many consumer products, including food packaging, personal care products and children’s toys. Previous studies have shown that BBP interferes with the body’s hormones and affects human reproduction and development, but the details of how it impacts reproduction have been unclear.
In the new study, researchers tested a range of doses of BBP on the nematode Caenorhabditis elegans and looked for abnormal changes in egg cells. They saw that at levels similar to those detected in humans, BBP interferes with how newly copied chromosomes are distributed into the sex cells. Specifically, BBP causes oxidative stress and breaks in the DNA strands, which lead to cell death and egg cells with the wrong number of chromosomes.
