Threatened Pandemics and Laboratory Escapes: Self-Fulfilling Prophecies
April 3rd, 2014Via: Bulletin of Atomic Scientists:
The public health danger from the escape, from laboratories, of viruses capable of causing pandemics has become the subject of considerable, well-merited discussion, spurred by “gain of function” experiments. The ostensible goal of these experiments— in which researchers manipulate already-dangerous pathogens to create or increase communicability among humans—is to develop tools to monitor the natural emergence of pandemic strains. Opponents, however, warn that the risk of laboratory escape of these high-consequence pathogens far outweighs any potential advance. These arguments appear in a variety of recent research papers, including Rethinking Biosafety in Research on Potential Pandemic Pathogens; The Human Fatality and Economic Burden of a Man-made Influenza Pandemic: A Risk Assessment; Containing the Accidental Laboratory Escape of Potential Pandemic Influenza Viruses; and Response to Letter by the European Society for Virology on “Gain-of-Function” Influenza Research.
The risk of a manmade pandemic sparked by a laboratory escape is not hypothetical: One occurred in 1977, and it occurred because of concern that a natural pandemic was imminent. Many other laboratory escapes of high-consequence pathogens have occurred, resulting in transmission beyond laboratory personnel. Ironically, these laboratories were working with pathogens to prevent the very outbreaks they ultimately caused. For that reason, the tragic consequences have been called “self-fulfilling prophecies.”
