Live Attenuated Swine Influenza Vaccine May Create New Pandemic Strains
August 21st, 2009Via: Institute of Science and Society:
The live attenuated swine flu vaccine intended for millions of children has dangerous side effects and is genetically unstable, risking generation of new pandemic strains should mass vaccinations go ahead.
…
A potential problem was observed in studies of LAIV as it encounters restrictive temperature in the lung. The viral polymerase function is reduced and virus replication, assembly, and release become impaired [12]. The morphology of the temperature restricted virus was affected and the virus particles contained high levels of heat shock protein. Impairment of the viral replicase is a matter of concern because replicase may create new pandemic strains. Restrictive replication of LAIV at the restrictive temperature occurs in multiple steps in the virus replication cycle [13]. Shedding of LAIV is observed in individuals between 5 to 49 years of age up to 11 days after vaccination, and vaccinated individuals were advised to avoid contact with severely inmunosuppressed individuals for a week after vaccination [14].
Millions of children may soon be vaccinated with LAIV. But there is a large deficit in scientific studies on the molecular biology of LAIV exposed to restrictive temperature. The restricted viruses are genetically unstable and may result in gene alterations that serve to seed pandemic strains of influenza. This possibility must be thoroughly investigated before we expose millions more people to such live viruses.
Research Credit: j crash
